MS Course

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Lublin & Reingold classification

National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Defining the clinical course of multiple sclerosis: results of an international survey. Neurology 1996; 46: 907-911

Relapsing-Remitting MS RR Characterized by clearly defined acute attacks with full recovery; or with sequelae and residual deficit upon recovery. Periods between disease relapses are characterized by lack of disease progression.
Primary Progressive MS PP Characterized by disease showing progression of disability from onset, without plateaus or remissions; or with occasional plateaus and temporary minor improvements.
Secondary Progressive MS SP Begins with an initial RR course, followed by progression of variable rate that may also include occasional relapses and minor remissions.
Progressive-Relapsing MS PR Shows progression from onset but with clear acute relapses with or without full recovery.